ChemicalBook CAS DataBase List 4-bromo-2-methoxy-1-nitrobenzene

4-bromo-2-methoxy-1-nitrobenzene synthesis

6synthesis methods

Product Name:4-bromo-2-methoxy-1-nitrobenzene
CAS Number:103966-66-1
Molecular formula:C7H6BrNO3
Molecular Weight:232.03

321-23-3

124-41-4

103966-66-1

GENERAL STEPS: To a solution of 4-bromo-2-fluoro-1-nitrobenzene (2.0 g, 9.09 mmol) in methanol (50 mL) was added a methanolic solution of 30% sodium methanolate (1.64 g, 9.09 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in water (30 mL) and extracted with ethyl acetate (2 x 30 mL). The organic phases were combined, washed with water, separated, dried over anhydrous magnesium sulfate, filtered, and the solvent was evaporated under reduced pressure to give 5-bromo-2-nitroanisole as a crystalline solid (2.1 g, 99% yield).1H-NMR (DMSO-d6): δ [ppm] 7.9 (d, 1H), 7.6 (s, 1H), 7.3 (d, 1H), 4.0 (s, 3H).

67-56-1 Synthesis

67-56-1
802 suppliers
$7.29/5ml-f

321-23-3
257 suppliers
$10.00/1g

124-41-4 Synthesis

124-41-4
725 suppliers
$12.00/25g

103966-66-1
138 suppliers
$7.00/100mg

Yield: 100%

Reaction Conditions:

at 60; for 3 h;Temperature;

Steps:

1.1; 2.1; 3.1 (1) Synthesis of compound III
Add 220g (1mol) of 4-bromo-2-fluoro-1-nitrotoluene, 1000ml of methanol to the reaction flask, add 108g (2mol) of sodium methoxide to 60°C, keep the temperature for 3 hours, and HPLC track the reaction until 4 The reaction of bromo-2-fluoro-1-nitrotoluene is complete; the reaction solution is concentrated, 1000 ml of water is added, and 1000 ml of ethyl acetate are added for layering, and the organic phase is concentrated to obtain 232 g of compound III. The molar yield: 100%.

References:

CN112300028, 2021, A Location in patent:Paragraph 0032; 0034-0035; 0052; 0054-0055; 0070; 0072-0073

321-23-3
257 suppliers
$10.00/1g

124-41-4 Synthesis

124-41-4
725 suppliers
$12.00/25g

103966-66-1
138 suppliers
$7.00/100mg

References

2398-37-0 Synthesis