4-Bromo-5-fluoro-2-nitrotoluene synthesis
- Product Name:4-Bromo-5-fluoro-2-nitrotoluene
- CAS Number:224185-19-7
- Molecular formula:C7H5BrFNO2
- Molecular Weight:234.02
446-33-3
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224185-19-7
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Yield:224185-19-7 83%
Reaction Conditions:
with sulfuric acid;bromine;silver nitrate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate
Steps:
7.a Synthesis of 4-bromo-5-fluoro-2-nitrotoluene
Example 7a Synthesis of 4-bromo-5-fluoro-2-nitrotoluene A mixture of 5-fluoro-2-nitrotoluene (1.00 g), silver nitrate (2.21 g), bromine (0.37 ml) and conc. sulfuric acid (6 ml) was stirred for 1 hour under cooling with ice. The reaction mixture was added dropwise to ice water and then subjected to extraction with chloroform. The organic layer was washed with saturated sodium hydrogencarbonate solution, dried with anhydrous magnesium sulfate and then concentrated at reduced pressure to give the titled compound in admixture with its regioisomer at a ratio of 5:3 (yield, 83%). 1H-NMR (CDCl3) δ:2.77(3H,s), 7.39(1H,d,J=11.0 Hz), 8.82(1H,d,J=7.1 Hz)
References:
Chugai Seiyaku Kabushiki Kaisha US6414005, 2002, B1
452-74-4
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224185-19-7
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259860-00-9
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224185-19-7
201 suppliers
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7787-70-4
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224185-19-7
201 suppliers
$7.00/1g