4-BROMOBENZOPHENONE synthesis
- Product Name:4-BROMOBENZOPHENONE
- CAS Number:90-90-4
- Molecular formula:C13H9BrO
- Molecular Weight:261.11
Yield:90-90-4 91%
Reaction Conditions:
with sodium hydroxide in toluene at 100; for 2 h;Schlenk technique;Suzuki Coupling;
Steps:
2. General Procedure for the Preparation of Dissymmetric Ketones
General procedure: An oven-dried Schlenk flask, equipped with a magnetic stir bar, septum and a condenser was charged with acyl chloride (1.0 mmol), arylboronic acid (1.0 mmol), NaOH (4 mmol) and 5.0 mL of toluene. The flask was immersed and stirred in an oil bath at 100 °C. Upon complete consumption of starting materials as determined by GC analysis, the water (10.0 mL) was added. The reaction mixture was extracted with diethyl ether (3 × 5.0 mL). The combined organic layer was collected, dried over anhydrous Na2SO4 and concentrated in vacuum to afford product which was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate = 9:1 or 8:2).
References:
Jadhav, Sanjay;Rashinkar, Gajanan;Salunkhe, Rajashri;Kumbhar, Arjun [Tetrahedron Letters,2017,vol. 58,# 33,p. 3201 - 3204] Location in patent:supporting information
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