Yield:927-58-2 100%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in dichloromethane at 0 - 20; for 4 h;

Steps:

1 Step 1: Preparation of 4-bromobutanoyl chloride
Into a 250-mL round-bottom flask, was placed 4-bromobutanoic acid (10.0 g, 59.88 mmol, 1.00 equiv), dichloromethane (100 mL), N,N-dimethylformamide (0.15 mL). This was followed by the addition of thionyl chloride (8.5 mL) dropwise with stirring at 0. The resulting solution was stirred for 4 h at room temperature. The resulting mixture was concentrated under vacuum. This resulted in 11.08 g (100%) of 4-bromobutanoyl chloride as light yellow oil.

References:

ARVINAS OPERATIONS, INC.;YALE UNIVERSITY;CREW, Andrew P.;HORNBERGER, Keith R.;WANG, Jing;CREWS, Craig M.;JAIME-FIGUEROA, Saul;DONG, Hanqing;QIAN, Yimin;ZIMMERMAN, Kurt WO2020/51564, 2020, A1 Location in patent:Paragraph 2301; 2302

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