4-CHLORO-2-FLUOROBENZALDEHYDE synthesis
- Product Name:4-CHLORO-2-FLUOROBENZALDEHYDE
- CAS Number:61072-56-8
- Molecular formula:C7H4ClFO
- Molecular Weight:158.56
Preparation of (4-chloro-2-fluorophenyl)methanol:
To a solution of 4-chloro-2-fluorobenzoic acid (300 mg) in THF (15 ml) was added, at 0 °C, LiAlH4 (130 mg). The suspension was stirred at 0°C for 16 hours. The reaction mixture was diluted using
446-30-0
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61072-56-8
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Yield:-
Steps:
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 °C
2: manganese(IV) oxide / acetonitrile / 24 h
References:
ACTELION PHARMACEUTICALS LTD;BUR, Daniel;GRISOSTOMI, Corinna;NAYLER, Oliver;REMEN, Lubos;VERCAUTEREN, Magali;WELFORD, Richard WO2015/75025, 2015, A1 ACTELION PHARMACEUTICALS LTD;BUR, Daniel;GRISOSTOMI, Corinna;KIMMERLIN, Thierry;REMEN, Lubos;SIENDT, Hervé;VERCAUTEREN, Magali;WELFORD, Richard WO2016/177690, 2016, A1
56456-49-6
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