4-Chlorobenzotrifluoride synthesis
- Product Name:4-Chlorobenzotrifluoride
- CAS Number:98-56-6
- Molecular formula:C7H4ClF3
- Molecular Weight:180.55
887144-94-7
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$19.00/1g
106-47-8
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$5.00/5G
98-56-6
405 suppliers
$11.00/25g
Yield:98-56-6 62%
Reaction Conditions:
Stage #1: 4-chloro-anilinewith hydrogenchloride in cis-1,2-Dichloroethylene;water; for 0.0833333 h;
Stage #2: with tert.-butylnitrite in cis-1,2-Dichloroethylene;water; for 0.333333 h;
Stage #3: Togni's reagent IIwith tetrakis(acetonitrile)copper(I)tetrafluoroborate;sodium carbonate in cis-1,2-Dichloroethylene;water at 50;
Steps:
3 Example three,1-trifluoromethyl-4-chlorobenzene synthesis
Weigh 0.064g 4-chloroaniline,Join with a magnetic stirrer 25mL reaction tube,A mixed solution of HCl (0.13 g) and DCEAfter 5 min of reaction, 0.062 g of t-BuONO was added to the reaction tube,And placed in a salt bath stirring reaction 20min.Weigh 0.3g Tony reagent α,0.314 g of tetraacetonitrile Boron tetrafluoroborate,0.034 g sodium bicarbonate,They are sequentially added to the reaction tube,The reaction was stirred at 50 ° C for 10-20 hours,After the reaction,The reaction solution was filtered,Washed and dried,Further purification by column chromatography gave 0.058 g of colorless liquid (yield 62%).
References:
CN106631680,2017,A Location in patent:Paragraph 0023; 0024
5216-25-1
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98-56-6
405 suppliers
$11.00/25g
1679-18-1
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129946-88-9
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98-56-6
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$11.00/25g
128796-39-4
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98-56-6
405 suppliers
$11.00/25g