4-Chloropiperidine synthesis
- Product Name:4-Chloropiperidine
- CAS Number:5382-18-3
- Molecular formula:C5H10ClN
- Molecular Weight:119.59
5570-77-4
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$14.00/5g
5382-18-3
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 3 h / 80 °C
1.2: NaBr / methanol / 18 h / 20 °C
2.1: 89 percent / acetonitrile / 18 h / 73 °C
3.1: tetrahydrofuran / 8 h / -15 - 20 °C
References:
Amato, Joseph S.;Chung, John Y. L.;Cvetovich, Raymond J.;Gong, Xiaoyi;McLaughlin, Mark;Reamer, Robert A. [Journal of Organic Chemistry,2005,vol. 70,# 5,p. 1930 - 1933]