Yield:-

Reaction Conditions:

with N-Bromosuccinimide in tetrachloromethane

Steps:

7.A 4-Difluoromethoxy-benzyl cyanide
(A) 270 g of 4-difluoromethoxytoluene in 800 ml of CCl₄ were initially introduced and 300 g of N-bromo-succinimide were added. After adding a pinch of azobisisobutyronitrile, the mixture was heated to the reflux temperature. After 8hours, it was cooled, the insoluble succinimide was filtered off and the residue on the filter was washed with CCl₄. The carbon tetrachloride was distilled off from the reaction solution and the crude product was purified by fractional distillation. 250 g of 4-difluoromethoxy-benzyl bromide were obtained. Boiling point=82°-5° C./0.4 mm Hg; n_D²⁰ =1.5200.

References:

Bayer Aktiengesellschaft US4284643, 1981, A

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