4-FLUOROPHENYLMAGNESIUM BROMIDE synthesis
- Product Name:4-FLUOROPHENYLMAGNESIUM BROMIDE
- CAS Number:352-13-6
- Molecular formula:C6H4BrFMg
- Molecular Weight:199.3
460-00-4
630 suppliers
$6.00/10g
352-13-6
191 suppliers
$40.00/50 mL
Yield:-
Reaction Conditions:
with iodine;magnesium in tetrahydrofuran at 68 - 70; for 1.5 h;Heating / reflux;
Steps:
1 1) 20% solution of 4-fluorophenylmagnesium bromide in tetrahydrofuran
53.5 g of magnesium turnings (2.2 mol) and 0.3 g of iodide are charged into a 4-litres reactor at room temperature under nitrogen. The mixture is then heated to 70°C and a solution of 369.5 g (2.11 mol) of 4-fluorobromobenzene in 1960 ml tetrahydrofuran (5.3 volumes on 4-fluorobromobenzene) is added drop wise, in one hour. After addition the mixture is heated to reflux temperature (68÷70°C) for 30 minutes, then it's cooled to 25°C. 2000g of a 20% solution of 4-fluorophenylmagnesium bromide in tetrahydrofuran are obtained (to be kept under nitrogen and protected from the light).
References:
Adorkem Technology SpA EP1506963, 2005, A1 Location in patent:Page/Page column 4
7439-95-4
0 suppliers
$11.60/0.9g
460-00-4
630 suppliers
$6.00/10g
352-13-6
191 suppliers
$40.00/50 mL
3612-18-8
170 suppliers
$6.00/1g
460-00-4
630 suppliers
$6.00/10g
352-13-6
191 suppliers
$40.00/50 mL
65399-05-5
158 suppliers
$37.00/100mg
109-54-6
159 suppliers
$9.00/1g
460-00-4
630 suppliers
$6.00/10g
352-13-6
191 suppliers
$40.00/50 mL
207683-94-1
10 suppliers
inquiry
109-54-6
159 suppliers
$9.00/1g
460-00-4
630 suppliers
$6.00/10g
352-13-6
191 suppliers
$40.00/50 mL