4-FORMYL-2-METHOXYPHENYL BENZOATE synthesis
- Product Name:4-FORMYL-2-METHOXYPHENYL BENZOATE
- CAS Number:790-16-9
- Molecular formula:C15H12O4
- Molecular Weight:256.25
121-33-5
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Yield:790-16-9 99%
Reaction Conditions:
with iodine;triethylamine;triphenylphosphine in dichloromethane at 0 - 20; for 0.333333 h;
Steps:
General procedure for the synthesis of phenolic esters
General procedure: To a solution of iodine (0.1573 g, 0.62 mmol) in CH2Cl2 (2 mL) was added with triphenylphosphine (0.1626 g, 0.62 mmol) in one portion at 0 oC. Phenol derivative (0.45mmol) and carboxylic acid (0.41 mmol) were subsequently added into the mixture,followed by addition of triethylamine (0.17 mL, 1.23 mmol) at 0 oC. The reaction mixture was allowed to warm up to room temperature and stirred until completion of thereaction (typically within 20 min). The crude mixture was concentrated under reduced pressure then purified by column chromatography (CC) using 5-10% ethyl acetate inhexane to give the desired phenolic ester product.
References:
Phakhodee, Wong;Duangkamol, Chuthamat;Pattarawarapan, Mookda [Tetrahedron Letters,2016,vol. 57,# 19,p. 2087 - 2089] Location in patent:supporting information
174840-51-8
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790-16-9
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393125-26-3
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790-16-9
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100-52-7
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121-33-5
1219 suppliers
$9.00/1g
790-16-9
19 suppliers
$95.00/500mg