4-Iodobenzotrifluoride synthesis
- Product Name:4-Iodobenzotrifluoride
- CAS Number:455-13-0
- Molecular formula:C7H4F3I
- Molecular Weight:272.01
402-43-7
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$6.00/10g
455-13-0
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$10.00/1g
Yield:455-13-0 95 %Chromat.
Reaction Conditions:
with copper oxide (I);L-proline;potassium iodide in ethanol at 110; for 30 h;Schlenk technique;Inert atmosphere;Sealed tube;
Steps:
2.2. General procedure for aryl and heteroaryl bromide-iodideexchange reaction
General procedure: A Schlenk tube was charged with Cu2O (7.2 mg, 10 mol%), l-proline (11.5 mg, 20 mol%), aryl (or heteroaryl) bromide (1 or 3,0.50 mmol), potassium iodide (KI) (249 mg, 0.75 mmol), and EtOH(1.5 mL) under nitrogen atmosphere. The Schlenk tube was sealedwith a teflon valve, and then the reaction mixture was stirred at110C for a period (the reaction progress was monitored by GCanalysis). After the reaction was completed, GC yield of high volatileproduct was determined using an appropriate internal standard(chlorobenzene or 1-chloro-4-methylbenzene) or the solvent wasremoved under reduced pressure. The residue obtained was puri-fied via silica gel chromatography (eluent: petroleum ether/ethylacetate = 10/1) to afford aryl iodides 2a-2o or heteroaryl iodides4a-4g.
References:
Feng, Xiujuan;Li, Lingyu;Yu, Xiaoqiang;Yamamoto, Yoshinori;Bao, Ming [Catalysis Today,2016,vol. 274,p. 129 - 132]
455-24-3
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455-13-0
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$10.00/1g
98-08-8
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$9.00/1g
455-13-0
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$10.00/1g
401-81-0
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$10.00/10g
444-29-1
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128796-39-4
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$10.00/5g
455-13-0
264 suppliers
$10.00/1g
455-14-1
531 suppliers
$5.00/10g
455-13-0
264 suppliers
$10.00/1g