4-METHOXY-2-METHYL-1-METHYLSULFANYL-BENZENE synthesis
- Product Name:4-METHOXY-2-METHYL-1-METHYLSULFANYL-BENZENE
- CAS Number:22583-04-6
- Molecular formula:C9H12OS
- Molecular Weight:168.2594
Yield:-
Reaction Conditions:
Stage #1: 4-bromo-3-methylanisolewith n-butyllithium in tetrahydrofuran;hexane at -78; for 1 h;
Stage #2: Dimethyldisulphide in tetrahydrofuran;hexane at 20; for 2 h;
Stage #3: with water;ammonium chloride in tetrahydrofuran;hexane;
Steps:
15.1.1
Step 1 : To the cold (-780C) solution of 2-bromo-5-methoxy toluene (8g, 0.04mol) in dryTHF (8OmL) under inert atmosphere, butyl lithium solution (1.6M solution in hexane; 36.8mL, 0.058mol) was added dropwise and the mixture was stirred for 1h at same temperature. Dimethyl disulphide (7.7mL, O.Oδmol) was then added dropwise and the
References:
WO2009/30467,2009,A2 Location in patent:Page/Page column 107-108
