(4-METHOXYPHENYLETHYNYL)TRIMETHYLSILANE& synthesis
- Product Name:(4-METHOXYPHENYLETHYNYL)TRIMETHYLSILANE&
- CAS Number:3989-14-8
- Molecular formula:C12H16OSi
- Molecular Weight:204.34
104-92-7
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$10.00/10g
81353-38-0
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$85.00/1g
3989-14-8
69 suppliers
$37.39/1g
Yield: 81%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);sodium acetate at 80; for 5 h;Inert atmosphere;Green chemistry;Stille Cross Coupling;
Steps:
Stille cross-coupling reaction of organotin reagents with aryl bromides in PEG-400; general procedure
General procedure: A mixture of aryl bromide 1 (0.5 mmol), organotin reagent 2(0.6 mmol), NaOAc (0.5 mmol) and Pd(PPh3)4 (0.005 mmol) inPEG-400 (2 mL) was stirred at 80 °C under an argon atmosphere for3-5 h until complete consumption of the aryl bromide was observed as judged by TLC. After being cooled to room temperature, the mixture was extracted three times with light petroleum ether (30-60°C) (3 × 10 mL). The combined organic phases were concentrated under reduced pressure and the residue was purified by flash column chromatography on silica gel [light petroleum ether (30-60 °C)/ethylacetate] to afford the desired product 3.
References:
Huang, Xue;Yao, Fang;Wei, Ting;Cai, Mingzhong [Journal of Chemical Research,2017,vol. 41,# 9,p. 547 - 550]
104-92-7
434 suppliers
$10.00/10g
1066-54-2
469 suppliers
$9.00/10g
3989-14-8
69 suppliers
$37.39/1g
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