4-Methyl-3-nitroaniline synthesis
- Product Name:4-Methyl-3-nitroaniline
- CAS Number:119-32-4
- Molecular formula:C7H8N2O2
- Molecular Weight:152.15
106-49-0
404 suppliers
$5.00/5G
119-32-4
266 suppliers
$15.00/25g
Yield:119-32-4 88%
Reaction Conditions:
Stage #1: p-toluidinewith sulfuric acid;uronium nitrate at 0 - 10; for 0.5 h;
Stage #2: with sodium hydroxide pH=~ 12;
Steps:
6.6.13.a
Sulfuric acid (365.8 g, 3.73 mol, 10 eq) was added drop wise to p-toluidine (40 g, 0.37 mol) at rt and stirred the contents to obtain a clear solution. Then Urea nitrate (45.5 g, 0.37 mol, 1 eq) was added at 0 - 1O0C and stirred the reaction mass for 30 min at the same temperature. Progress of the reaction was monitored by TLC (30% ethyl acetate/hexane, Rf-0.5), On completion of the reaction, reaction mixture was quenched with ice water and the solid formed was filtered. Solid obtained was taken in 20% NaOH solution (up to pH~12) and filtered. Washed the solid and dried to yield the required product as an yellow colored solid (50 g, 88% yield).
References:
WO2010/127855,2010,A1 Location in patent:Page/Page column 121
121-14-2
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$25.39/1.2mL
119-32-4
266 suppliers
$15.00/25g
7664-93-9
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$23.30/1090731000
106-49-0
404 suppliers
$5.00/5G
119-32-4
266 suppliers
$15.00/25g
121-14-2
0 suppliers
$25.39/1.2mL
95-80-7
264 suppliers
$12.00/1mg
119-32-4
266 suppliers
$15.00/25g
99-55-8
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$6.00/25g