4-(Methylsulfonyl)phenol synthesis
- Product Name:4-(Methylsulfonyl)phenol
- CAS Number:14763-60-1
- Molecular formula:C7H8O3S
- Molecular Weight:172.2
1073-72-9
14763-60-1
Step 2. Synthesis of 4-(methylsulfonyl)phenol Oxone (0.99 g, 6.5 mmol) was added batchwise to a solution of 4-(methylthio)phenol (0.50 g, 3.2 mmol) in ethanol (10.0 mL). Subsequently, water (10.0 mL) was added at room temperature. The reaction mixture was stirred for 18 h, after which it was partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated under vacuum to afford 4-(methylsulfonyl)phenol as a semi-solid (0.60 g, 96% yield). LCMS calculated value C7H9O3S ([M + H]+): m/z = 173.0; measured value: 173.0.
1073-72-9
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14763-60-1
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Yield:14763-60-1 96%
Reaction Conditions:
with Oxone in ethanol;water at 20; for 18 h;
Steps:
75.2 Step 2. 4-(methylsulfonyl)phenol
Step 2. 4-(methylsulfonyl)phenol Oxone (0.99 g, 6.5 mmol) (Aldrich cat22803-6) was added in portions to a solution of 4-(methylthio)phenol (0.50 g, 3.2 mmol) in ethanol (10.0 mL) and water (10.0 mL) at room temperature. The reaction mixture was stirred for 18 h then partitioned between ethyl acetate and water. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated in vacuo to afford 4-(methylsulfonyl)phenol as a semisolid (0.60 g, 96%). LCMS calculated for C7H9O3S (M+H)+: m/z = 173.0; found: 173.0.
References:
WO2015/164480,2015,A1 Location in patent:Page/Page column 106; 107
3466-32-8
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14763-64-5
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