4-NITROISOQUINOLINE synthesis
- Product Name:4-NITROISOQUINOLINE
- CAS Number:36073-93-5
- Molecular formula:C9H6N2O2
- Molecular Weight:174.16
192182-56-2
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Yield: 68%
Reaction Conditions:
with bismuth (III) nitrate pentahydrate in benzene at 70 - 80; for 2 h;Inert atmosphere;
Steps:
General procedure for ipso-nitration of aryl and heteroaryl boronic acids:
General procedure: The mixture of aryl boronic acid (50 mg, 1 equiv) and bismuth (III) nitrate (2 equiv) in toluene or benzene (2 mL) was refluxed for 1.5-2 h. Reaction mixture was allowed to cool to room temperature and was filtered through Whatman filter paper. Residue was washed with ethyl acetate followed by DCM. Combined organic layers were evaporated on a rotary evaporator. Crude product was purified by silica gel column chromatography (?100-200) using EtOAc/hexane (1:99 to 5:95) as mobile phase.
References:
Yadav, Rammohan R.;Vishwakarma, Ram A.;Bharate, Sandip B. [Tetrahedron Letters,2012,vol. 53,# 44,p. 5958 - 5960,3] Location in patent:supporting information
119-65-3
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