4-TERT-BUTYLPHTHALONITRILE synthesis
- Product Name:4-TERT-BUTYLPHTHALONITRILE
- CAS Number:32703-80-3
- Molecular formula:C12H12N2
- Molecular Weight:184.24
52319-96-7
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32703-80-3
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Yield:32703-80-3 99.4%
Reaction Conditions:
with phosphorus pentoxide in acetonitrileReflux;
Steps:
1-3
In a three-necked flask, dissolve 220 g (1.0 mol) of 4-tert-butylphthalamide in 1500 mL of solvent acetonitrile, add 250 g of phosphorus pentoxide in batches, reflux the reaction, and concentrate after the reaction, and pour the remainder Into the ice-water mixture, a white solid precipitated, and 183 g of white 4-tert-butylphthalonitrile was obtained by filtration, with a yield of 99.4% and a gas phase purity of 99.3%.
References:
Hunan Daoshi Pharmaceutical Technology Co., Ltd.;Xiao Xuhui;Peng Yong;Li Yuan;Guo Libing CN108047089, 2020, B Location in patent:Paragraph 0023; 0028; 0029; 0034; 0035; 0040-0041
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32703-80-3
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