1H-Pyrazole, 1-(2-chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)- synthesis
- Product Name:1H-Pyrazole, 1-(2-chlorophenyl)-5-(2-furanyl)-3-(trifluoromethyl)-
- CAS Number:437711-24-5
- Molecular formula:C14H8ClF3N2O
- Molecular Weight:312.67
326-90-9
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41052-75-9
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$5.00/5g
437711-24-5
24 suppliers
$282.75/1g
Yield:437711-24-5 85%
Reaction Conditions:
Stage #1: 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione;o-chlorophenylhydrazine hydrochloride in acetic acid at 80; for 18 h;
Stage #2: with sodium hydroxide in water;ethyl acetate;
Steps:
1.a
Into a 500 mL flask was weighed 25.0 g (139.6 mmol) of 2-chlorophenylhydrazine hydrochloride, 27.4 g (153 mmol) of 4,4,4-trifluoro-1-furan-2-yl-butane-1,3-dione, and 200 mL of acetic acid. The resulting solution was heated at 80 °C for 18 h then was cooled and was washed into a separatory funnel with 1.0 M NaOH and ethyl acetate. The ethyl acetate was separated, washed with 1.0 M NaOH, brine, dried (Na2SO4), and was concentrated in vacuo. The residue was filtered through a short column of silica gel affording 1-(2- chlorophenyl)-5-furan-2-yl-3-trifluoromethyl-1H-pyrazole as a brown oil, yield: 37.31 g (85%); MS (ES): 313 [M+H]+.
References:
WO2008/73825,2008,A1 Location in patent:Page/Page column 134
1192-62-7
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437711-24-5
24 suppliers
$282.75/1g