2,2-Dimethylpropanoic acid [[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphinylidene]bis(oxymethylene) ester synthesis
- Product Name:2,2-Dimethylpropanoic acid [[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphinylidene]bis(oxymethylene) ester
- CAS Number:441785-26-8
- Molecular formula:C22H34N5O7P
- Molecular Weight:511.5084
![PHOSPHONIC ACID, [[[1-[(2-AMINO-9H-PURIN-9-YL)METHYL]CYCLOPROPYL]OXY]METHYL]- (9CI)](/CAS/GIF/441785-25-7.gif)
Yield:441785-26-8 38.5%
Reaction Conditions:
Stage #1: Besifovirwith triethylamine in 1-methyl-pyrrolidin-2-one at 60; for 0.5 h;
Stage #2: Chloromethyl pivalate in 1-methyl-pyrrolidin-2-one at 25; for 48 h;
References:
Choi, Jong-Ryoo;Cho, Dong-Gyu;Roh, Kee Y.;Hwang, Jae-Taeg;Ahn, Sinbyoung;Jang, Hyun S.;Cho, Woo-Young;Kim, Kyong W.;Cho, Young-Gyo;Kim, Jeongmin;Kim, Yong-Zu [Journal of Medicinal Chemistry,2004,vol. 47,# 11,p. 2864 - 2869]
![[[[1-(Hydroxymethyl)cyclopropyl]oxy]methyl]phosphonic acid bis(1-methylethyl) ester](/CAS/20150408/GIF/441784-85-6.gif)
441784-85-6
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441785-26-8
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![[[[1-[[(Methylsulfonyl)oxy]methyl]cyclopropyl]oxy]methyl]phosphonic acid bis(1-methylethyl) ester](/CAS/20150408/GIF/441784-86-7.gif)
441784-86-7
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441785-26-8
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441784-88-9
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441784-84-5
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