1H-Isoindol-1-one, 2,3-dihydro-2-(4-methoxyphenyl)- synthesis
10synthesis methods
- Product Name:1H-Isoindol-1-one, 2,3-dihydro-2-(4-methoxyphenyl)-
- CAS Number:4778-82-9
- Molecular formula:C15H13NO2
- Molecular Weight:239.27
Yield:4778-82-9 96.61%
Reaction Conditions:
at 140; for 2 h;
Steps:
10
Example 10:In a 25mL round bottom flask,Add 2.28g of methyl 2-bromomethylbenzoate and 1.23g of p-methoxyaniline,Heated up to 140 ° C,Conduct an open reaction for 2h,The progress of the reaction was checked by TLC.When the reaction is complete,Add 10ml of ethyl acetateThe ester was stirred for 0.5h, cooled to 25C and filtered. The ethyl acetate was recrystallized and dried to give white 2- (4-methoxyphenyl) isoindolin-1-one powder with a yield of 96.61% and a purity of 99.13%.
References:
CN110498759,2019,A Location in patent:Paragraph 0031
