5-(3,4-DICHLOROPHENYL)CYCLOHEXANE-1,3-DIONE synthesis
- Product Name:5-(3,4-DICHLOROPHENYL)CYCLOHEXANE-1,3-DIONE
- CAS Number:27463-42-9
- Molecular formula:C12H10Cl2O2
- Molecular Weight:257.11
Yield:-
Reaction Conditions:
with potassium hydroxide in ethanol;water;
Steps:
3 Preparation of 7-Chloro-3-(3,4-dichlorophenyl)-1-[[2(diethylamino)ethyl]imino]-1,3,4,10-tetrahydro-9(2H)acridinone.
A solution of 1.3 g of sodium metal in 30 ml of ethanol is treated with 9 g of diethylmalonate and an ethanolic solution of 12.1 g of 3,4-dichlorobenzalacetone, heated under reflux for 15 min, cooled and concentrated to dryness in vacuo. The residue is treated with 400 ml of water containing 7 g of 80% potassium hydroxide pellets and heated under reflux for 2 hr. Insoluble material is removed and the filtrate is acidified with concentrated sulfuric acid, heated under reflux until carbon dioxide evolution ceases, cooled, filtered, washed with water and dried. Recrystallization from 2-propanol gives 5-(3,4-dichlorophenyl)-1,3-cyclohexanedione; mp 198°-200° C.
References:
US4291034,1981,A
74546-02-4
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27463-42-9
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27463-42-9
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