5,7-DICHLORO-4-HYDROXYQUINOLINE synthesis
- Product Name:5,7-DICHLORO-4-HYDROXYQUINOLINE
- CAS Number:21873-52-9
- Molecular formula:C9H5Cl2NO
- Molecular Weight:214.05
93514-82-0
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21873-52-9
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$144.00/500mg
171850-30-9
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$87.00/1g
Yield:21873-52-9 78%
Reaction Conditions:
with sulfuric acid
Steps:
3 Example 3
Example 3 (Manufacture of 5,7-Dichloro-4-hydroxyquinoline) 5,7-Dichloro-3-ethoxycarbonyl-4-hydroxyquinoline (114.4 g; 0.4 mole) and 343.2 g of 70% sulfuric acid were charged in a 1,000 ml four-necked flask equipped with stirrer, thermometer and distilling tube and the mixture was heated at 150° C. with stirring. Reaction was continued by heating up to 165° C. during three hours together with evaporation of the by-produced ethanol outside the reaction system. The reaction product was analyzed by liquid chromatography whereupon and it was found that the starting 5,7-dichloro-3-ethoxycarbonyl-4-hydroxy-quinoline disappeared and that 5,7-dichloro-3-carboxy-4-hydroxyquinoline in 22% yield and 5,7-dichloro-4-hydroxyquinoline in 78% yield were produced.
References:
US5731440,1998,A
626-43-7
338 suppliers
$10.00/1g
21873-52-9
14 suppliers
$144.00/500mg
131123-76-7
87 suppliers
$47.00/5mg
21873-52-9
14 suppliers
$144.00/500mg
171850-30-9
38 suppliers
$87.00/1g
21873-52-9
14 suppliers
$144.00/500mg
87-13-8
458 suppliers
$5.00/5g
626-43-7
338 suppliers
$10.00/1g
21873-52-9
14 suppliers
$144.00/500mg