5-BROMO-3-ETHOXY-2-HYDROXYBENZALDEHYDE synthesis
- Product Name:5-BROMO-3-ETHOXY-2-HYDROXYBENZALDEHYDE
- CAS Number:20035-44-3
- Molecular formula:C9H9BrO3
- Molecular Weight:245.07
492-88-6
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$13.43/1gm:
20035-44-3
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$64.00/250mg
Yield:20035-44-3 86%
Reaction Conditions:
with bromine;sodium acetate;acetic acid at 20; for 0.5 h;
Steps:
11.a a) 5- bromo-3-ethoxy-2-hydroxybenzaldehyde Preparation of 4a:
Take compound 1a (1.50mmol, 249.3mg) was dissolved in acetic acid 9mL added successively anhydrous sodium acetate (1.95mmol, 159.9mg) bromine (2.40mmol, 383.6mg, stirred for 30 minutes at room temperature. After the reaction was removed by distillation under reduced pressure the solvent, water / dichloromethane extraction, the organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and distilled under reduced pressure to give the crude product was purified by column chromatography eluting with petroleum ether condition: ethyl acetate = 8: 1 to yield 4a as a yellow solid 316.2mg, yield 86.0%, mp 91.0-92.7 .
References:
CN103265517,2016,B Location in patent:Paragraph 0146
24677-78-9
270 suppliers
$8.00/1g
20035-44-3
18 suppliers
$64.00/250mg