ChemicalBook CAS DataBase List 5-BROMOBENZO[B]THIOPHENE

5-BROMOBENZO[B]THIOPHENE synthesis

12synthesis methods

Product Name:5-BROMOBENZO[B]THIOPHENE
CAS Number:4923-87-9
Molecular formula:C8H5BrS
Molecular Weight:213.09

5-Bromobenzothiophene is a thiophene derivative and can be used as a pharmaceutical intermediate. It can be synthesized by ring-closure reaction of 1-Bromo-4-[(2,2-diethoxyethyl)thio]benzene with PPA in chlorobenzene.

105126-89-4
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4923-87-9
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Yield:4923-87-9 105 g

Reaction Conditions:

with phosphorus pentoxide in toluene at 80 - 125; for 47 h;

Steps:

4.2

_{(2) Add 600ml of toluene and 50g of polyphosphoric acid into a 2L four-necked flask, stir and raise the temperature to 80°C, Add 50g of phosphorus pentoxide, and then increase the temperature to 115-120°C, Start slowly adding step intermediates while controlling the kettle temperature at 120-125°C. It takes 45 hours. After the addition is complete, keep it at the same temperature for 2 hours. The reaction is complete. Cool down to 50°C, add 200g water to the reaction solution, separate into layers, and take the organic layer Under reduced pressure distillation, 105 g of 5-bromobenzothiolane was obtained.}

References:

CN111423409,2020,A Location in patent:Paragraph 0046; 0049

1-BROMO-4-(2,2-DIETHOXY-ETHYLSULFANYL)-BENZENE

96804-05-6
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4923-87-9
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References

1,3-Benzodioxole-5-propanoic acid, 7-methoxy-α-thioxo-

874497-39-9
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4923-87-9
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References

5-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID

7312-10-9
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$33.00/250mg

4923-87-9
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References

Benzo[b]thiophene-3-ol, 5-bromo-2,3-dihydro-

911472-08-7
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4923-87-9
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References

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5-Bromo-2-hexylthiophene 5-BroMobenzothiophene-2-carboxylic Acid Methyl Ester 5-BROMOBENZO[B]THIOPHENE-3-CARBOXYLIC ACID (5-BROMO-3-BENZO[B]THIENYL)METHANOL 3-Bromo-1-benzothiophene 5-BROMO-3-CYANOMETHYL-BENZO[B]THIOPHENE 5-BROMOBENZO[B]THIOPHENE-2-CARBONITRILE 5-BROMOBENZO[B]THIOPHENE-2-CARBALDEHYDE 2-BROMOBENZO[B]THIOPHENE

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5-BROMOBENZO[B]THIOPHENE synthesis

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