5-Bromoindole synthesis
- Product Name:5-Bromoindole
- CAS Number:10075-50-0
- Molecular formula:C8H6BrN
- Molecular Weight:196.04
1196980-99-0
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10075-50-0
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Yield:10075-50-0 99%
Reaction Conditions:
with water;1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran at 20; for 24 h;
Steps:
4.3. General procedures for the deprotection of N-pivaloylindoles
General procedure: Method B: A mixture of DBU (4 equiv) and water (2 equiv) was added to a solution of the suitable 1-pivaloyl derivatives (1 equiv) in THF (3 mL×mmol) and was stirred at rt until the disappearance of the starting indole. The reaction mixture was eluyed with EtOAc (10 mL) and was washed with a saturated aqueous NH4Cl solution (4 mL×mmol). The aqueous layer was extracted with EtOAc (2×15 mL). The combined organic layers were dried over Na2SO4 and evaporated to afford the corresponding unprotected compound.
References:
Ruiz, Míriam;Sánchez, J. Domingo;López-Alvarado, Pilar;Menéndez, J. Carlos [Tetrahedron,2012,vol. 68,# 2,p. 705 - 710] Location in patent:experimental part
26807-69-2
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10406-06-1
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$6.00/100mg
10075-50-0
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75-07-0
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$14.00/5mL
106-40-1
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10075-50-0
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22190-33-6
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10075-50-0
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