5-Bromosalicylic acid synthesis
- Product Name:5-Bromosalicylic acid
- CAS Number:89-55-4
- Molecular formula:C7H5BrO3
- Molecular Weight:217.02
69-72-7
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$5.00/10g
89-55-4
271 suppliers
$9.00/5g
Yield:89-55-4 95%
Reaction Conditions:
with tetrapropylammonium nonabromide in dichloromethane at 23; for 0.5 h;Inert atmosphere;
Steps:
Brominations with Pr4NBr9; General Procedure A
General procedure: A round-bottom flask equipped with a magnetic stir bar and a rubber septum was charged with Pr4NBr9 (0.66 mmol, 0.33 mol%) and CH2Cl2 (1 mL). The homogeneous solution was stirred and cooled to 0 °C if not described otherwise (partial precipitation of the nonabromide can occur at this point). The substrate (2.0 mmol, 1.0equiv) was added and the reaction allowed to warm to 23 °C (attention: exothermic reaction) After the reported reaction time the dark-red color of the nonabromide had vanished and TLC control showed completion of the reaction. The reaction was quenched by addition of sat. aq Na2S2O3 (2 mL) and transferred to a separation funnel. H2O was added (15 mL) followed by extraction with Et2O (4 × 20 mL) if not described otherwise. The organic layers were combined, washed with H2O (4 × 15 mL), dried (Na2SO4), filtered, and concentrated under reduced pressure to give the crude product.
References:
Beck, Thorsten M.;Haller, Heike;Streuff, Jan;Riedel, Sebastian [Synthesis,2014,vol. 46,# 6,art. no. SS-2013-Z0693-FA,p. 740 - 747]
21740-00-1
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89-55-4
271 suppliers
$9.00/5g
69-72-7
1320 suppliers
$5.00/10g
3883-95-2
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$20.00/1g
89-55-4
271 suppliers
$9.00/5g
3147-55-5
172 suppliers
$19.00/5g