5-CHLORO-1,3-BENZODIOXOLE synthesis
- Product Name:5-CHLORO-1,3-BENZODIOXOLE
- CAS Number:7228-38-8
- Molecular formula:C7H5ClO2
- Molecular Weight:156.57
274-09-9
486 suppliers
$5.00/5g
7228-38-8
86 suppliers
$25.00/1g
Yield: 96.2%
Reaction Conditions:
with chlorine in chloroform at 35; for 2 h;Temperature;
Steps:
1.1 Step 1: Preparation of 5-chlorobenzodioxole
Example 1: In a reaction flask equipped with a stirrer, a reflux condenser, and a dropping funnel, 0.5000 g of benzodioxole, 10 ml of chloroform was added, and the mixture was stirred and dissolved in a dropping funnel, and 5 ml of chloroform was added. Slowly pass 1.005 g of chlorine gas, control the temperature of the reaction solution to 35 ° C, and add chlorine gas to the chloroform solution for about 5 minutes. After the completion of the addition, the reaction was stirred for 2 hours, then washed twice with water, and the organic layer was combined, washed with brine, dried over anhydrous sodium sulfate and evaporated. The yield is 96.2%.
References:
SOUTHWEST UNIV FOR NATIONALITIES;Southwest University for Nationalities;YANG HONGJUN;Yang Hongjun;FENG YUCHUAN;Feng Yuchuan;CHEN CHENG;Chen Cheng CN107840840, 2018, A Location in patent:Paragraph 0017; 0020; 0021; 0022; 0023; 0024
94839-07-3
226 suppliers
$10.00/1g
7228-38-8
86 suppliers
$25.00/1g
274-09-9
486 suppliers
$5.00/5g
7228-38-8
86 suppliers
$25.00/1g
6120-31-6
41 suppliers
$115.00/500mg