5-CHLORO-2-(4-FLUOROPHENYL)-BENZIMIDAZOLE synthesis
3synthesis methods
- Product Name:5-CHLORO-2-(4-FLUOROPHENYL)-BENZIMIDAZOLE
- CAS Number:21627-71-4
- Molecular formula:C13H8ClFN2
- Molecular Weight:246.67
Yield:21627-71-4 86%
Reaction Conditions:
with potassium fluoride;tetrabutyl ammonium fluoride;isopropyl alcohol;silver(I) triflimide in water at 90; for 48 h;
Steps:
Typical procedure for 10a
General procedure: 1,2-Diaminobenzene (108 mg), benzyl alcohol (128.7 mg), AgNTf2 (116 mg), KF (17.4 mg), TBAF (74 mg), iPrOH (180 mg) and TPT-ZnMS (10 mg) were added to a reaction tube. Water (3.5 mL) and a stir bar were added to the reaction tube, and stirred for 48 h in 90 oC under air atmosphere.
References:
Zhu, Guanxin;Duan, Zheng-Chao;Zhu, Haiyan;Ye, Dongdong;Wang, Dawei [Chinese Chemical Letters,2022,vol. 33,# 1,p. 266 - 270] Location in patent:supporting information
