5-CHLORO-2,6-DIMETHOXY-4-METHYL-8-NITROQUINOLINE synthesis
- Product Name:5-CHLORO-2,6-DIMETHOXY-4-METHYL-8-NITROQUINOLINE
- CAS Number:189746-21-2
- Molecular formula:C12H11ClN2O4
- Molecular Weight:282.68
6340-55-2
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$55.00/0.5g
189746-21-2
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: methanol / 43 h / Reflux; Inert atmosphere
2.1: sulfuryl dichloride / acetic acid / 0.5 h / 60 °C / Inert atmosphere
3.1: phosphorus pentoxide / triethyl phosphate / 1 h / 20 °C / Inert atmosphere
3.2: 0.25 h / 35 °C / Reflux; Inert atmosphere
References:
Shiraki, Hiroaki;Kozar, Michael P.;Melendez, Victor;Hudson, Thomas H.;Ohrt, Colin;Magill, Alan J.;Lin, Ai J. [Journal of Medicinal Chemistry,2011,vol. 54,# 1,p. 131 - 142]
189746-20-1
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189746-21-2
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