5'-CHLORO-2'-HYDROXY-4'-METHYLPROPIOPHENONE synthesis
2synthesis methods
- Product Name:5'-CHLORO-2'-HYDROXY-4'-METHYLPROPIOPHENONE
- CAS Number:22362-65-8
- Molecular formula:C10H11ClO2
- Molecular Weight:198.65
Preparation by Fries rearrangement of 4-chloro- 3-methyl-phenyl propionate (b.p.760 250°) in the presence of aluminium chloride, at 155° for 30 min or at 120° for 10 min (94%).
Yield:22362-65-8 94%
Reaction Conditions:
with titanium tetrachloride in neat (no solvent) at 100; for 6 h;Inert atmosphere;
References:
Chanda, Tanmoy;Chowdhury, Sushobhan;Koley, Suvajit;Anand, Namrata;Singh, Maya Shankar [Organic and Biomolecular Chemistry,2014,vol. 12,# 45,p. 9216 - 9222] Location in patent:supporting information
