5-Chloro-2-methoxyaniline synthesis
- Product Name:5-Chloro-2-methoxyaniline
- CAS Number:95-03-4
- Molecular formula:C7H8ClNO
- Molecular Weight:157.6
89-21-4
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$12.00/5g
95-03-4
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$13.00/25g
Yield:95-03-4 98%
Reaction Conditions:
with iron(III) chloride;pyrographite;hydrazine hydrate in methanol for 16 h;Reflux;
Steps:
Intermediate s: 5-Chloro-2-methoxyaniline
Intermediate s: 5-Chloro-2-methoxyaniline Hydrazine hydrate (80%, 186 g, 2.975 mol) was added drop-wise to a refluxing mixture of 4-chloro-1-methoxy-2-nitrobenzene (Intermediate 4, 93 g, 0.496 mol), iron trichloride (9.3 g, 10% wt) and active carbon (9.3 g, 10% wt) in methanol (1 L). After the addition, the reaction mixture was stirred at reflux for 16 h, the reaction mixture was filtered and the solvent evaporated from the filtrate under vacuum. The residue was washed with petroleum ether (2 L) to give 5-chloro-2-methoxyaniline as a white solid (76.7 g, 98%). 1H NMR (300MHz, CDCI3) δ 6.67-6.65 (m, 3H), 3.83 (bs, 2H), 3.81 (s, 3H).
References:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED;BOUILLOT, Anne Marie Jeanne;MIRGUET, Olivier;LIDDLE, John;WALKER, Ann, Louise WO2015/91647, 2015, A1 Location in patent:Page/Page column 41
60468-21-5
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95-03-4
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$13.00/25g
623-12-1
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95-03-4
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89-61-2
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95-03-4
123 suppliers
$13.00/25g
106-48-9
500 suppliers
$10.00/5 g
95-03-4
123 suppliers
$13.00/25g