5-chloro-N-(2-chlorophenyl)-2-hydroxy-benzaMide synthesis
2synthesis methods
- Product Name:5-chloro-N-(2-chlorophenyl)-2-hydroxy-benzaMide
- CAS Number:6626-92-2
- Molecular formula:C13H9Cl2NO2
- Molecular Weight:282.12
5-chloro-N-(2-chlorophenyl)-2-hydroxy-benzamide is produced by heating equimolar quantities of 3-chlorosalicylic acid and 2-chloroaniline in the presence of PCl3 in chlorobenzene or toluene.
Yield:6626-92-2 56%
Reaction Conditions:
with phosphorus trichloride in toluene;Inert atmosphere;Reflux;
References:
Barker, William T.;Basak, Akash K.;Hendricks, Tyler A.;Jania, Leigh A.;Koller, Beverly H.;Marrujo, Santiana A.;Melander, Christian;Melander, Roberta J.;Nemeth, Ansley M.;O'Connor, Patrick M.;Sullivan, Ashley E.;Weig, Alexander W. [ChemMedChem,2019] Location in patent:supporting information
