5-FLUORO-2-METHOXYBENZONITRILE synthesis
- Product Name:5-FLUORO-2-METHOXYBENZONITRILE
- CAS Number:189628-38-4
- Molecular formula:C8H6FNO
- Molecular Weight:151.14
704-04-1
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$78.20/1g
189628-38-4
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$8.00/100mg
Yield:-
Reaction Conditions:
with trichlorophosphate in N,N-dimethyl-formamide
Steps:
64 Preparation 64
Preparation 64 At 5 °C was added phosphorus oxychloride (2.33ml) to N,N-dimethylformamide (15ml). Stirred 30 minutes at 5 °C under nitrogen and added 5-fluoro-2-methoxybenzamide (1.40g). Stirred 1 hour at 5°C. Poured into water (100ml), allowed to stand for 30 minutes, collected by filtration, washed with water, and air dried to give 5-fluoro-2-methoxybenzonitrile (1.45g) as white crystals. mp:113-114°C IR(KBr):2229cm-1 MS:152(M+1) NMR(DMSO, δ):3.90(3H,s), 7.27(1H,dd,J=9.4Hz,4.2Hz), 7.58(1H,ddd,J=9.2Hz, 9.2Hz,3.2Hz), 7.75(1H,dd,J=8.2Hz,3.2Hz)
References:
FUJISAWA PHARMACEUTICAL CO., LTD. EP1264820, 2002, A1
506-78-5
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179897-94-0
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189628-38-4
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$8.00/100mg
452-08-4
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143-33-9
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189628-38-4
136 suppliers
$8.00/100mg