5-HYDROXYMETHYLISOQUINOLINE synthesis
- Product Name:5-HYDROXYMETHYLISOQUINOLINE
- CAS Number:76518-57-5
- Molecular formula:C10H9NO
- Molecular Weight:159.18
80278-67-7
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76518-57-5
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$200.00/100mg
Yield:76518-57-5 94%
Reaction Conditions:
with methanol;sodium tetrahydridoborate at 0 - 5; for 2 h;Inert atmosphere;
Steps:
44.1 Step 1: Isoquinolm-5-ylmethanol (44.2)
[00516] To a solution of intermediate 44.1 (300 mg, 1.91 mmol) in MeOH (8 mL) cooled to 0-5 °C, sodium borohydride (87 mg, 2.29 mmol) was added, and the mixture was stirred for 2 h. The reaction was then poured into EtOAc (30 mL), washed with brine (20 mL), dried over Na2SC>4, and concentrated under reduced pressure, to afford 285 mg of the intermediate 44.2. [00517] Yield: 94% [00518] MS-ESI(+) m/z: 160.3 (M+H).
References:
WO2021/170658,2021,A1 Location in patent:Paragraph 00516-00518
16675-59-5
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76518-57-5
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$200.00/100mg
34784-04-8
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$7.00/1g
76518-57-5
50 suppliers
$200.00/100mg