5-HYDROXYPHTHALIDE synthesis
- Product Name:5-HYDROXYPHTHALIDE
- CAS Number:55104-35-3
- Molecular formula:C8H6O3
- Molecular Weight:150.13
4741-62-2
48 suppliers
$78.00/100mg
55104-35-3
72 suppliers
$59.00/100mg
Yield:55104-35-3 83%
Reaction Conditions:
with dichloromethane;boron tribromide at 0 - 20;Inert atmosphere;
Steps:
4 Synthesis of 6-hydroxy isobenzofuran-1(3H)-one
A 25 mL two necked round bottom flask, under nitrogen atmosphere, was charged with 6-methoxy isobenzofuran-1(3H)-one 1 (100 mg, 0.61 mmol) and anhydrous dichloromethane (5 mL).
The resulting mixture was magnetically stirred and cooled in ice bath for 10 min.
After that, 1.8 mL of 1.0 mol L-1 BBr3 solution in dichloromethane (1.8 mmol) was added dropwise.
Then, the reaction mixture under continuous magnetic stirring was allowed to warm up to room temperature.
Subsequently, 5 mL of distilled water were added and the mixture was transferred to a separatory funnel and extracted with ethyl acetate (3 * 25 mL).
The combined organic extracts were dried over magnesium sulphate, filtrated and concentrated under reduced pressure.
The residue was purified by column chromatography eluted with hexane-ethyl acetate (2:1 v/v) to afford compound
References:
Teixeira;Pereira;Da Silva;Guilardi;Paix?o;Anconi;De Almeida;Ellena;Forlani [Journal of Molecular Structure,2014,vol. 1061,# 1,p. 61 - 68]
1411945-89-5
0 suppliers
inquiry
55104-35-3
72 suppliers
$59.00/100mg
64169-34-2
353 suppliers
$12.00/5G
55104-35-3
72 suppliers
$59.00/100mg
65399-05-5
158 suppliers
$37.00/100mg
55104-35-3
72 suppliers
$59.00/100mg
201230-82-2
1 suppliers
inquiry
620-24-6
250 suppliers
$6.00/1g
55104-35-3
72 suppliers
$59.00/100mg