5-Iodovanillin synthesis
- Product Name:5-Iodovanillin
- CAS Number:5438-36-8
- Molecular formula:C8H7IO3
- Molecular Weight:278.04
121-33-5
1219 suppliers
$9.00/1g
5438-36-8
154 suppliers
$29.00/5g
Yield:5438-36-8 99%
Reaction Conditions:
with dihydrogen peroxide;iodine in water; for 0.5 h;Sonication;
Steps:
3.8. 4-Hydroxy-3-iodo-5-methoxybenzaldehyde (2i)
General procedure: General Procedure for Ultrasound-Promoted Iodination of Aromaticand Heteroaromatic Compounds: Hydrogen peroxide 30% (m/v) (4-8 mmol) was added to a suspension of theappropriate aromatic or heteroaromatic compound (1a-q) (2 mmol) and moleculariodine (2-4 mmol) in distilled water (10 mL). The mixture was sonicated and the progressof reaction was monitored by thin-layer chromatography (TLC). Afterward, asaturated sodium thiosulfate aqueous solution (10 mL) was added to the mixture,which was extracted with ethyl acetate (320mL). The organic phase was dried overMgSO4. After filtration, the solvent was evaporated under reduced pressure. The residuewas purified by column chromatography on silica gel using an appropriate eluent,affording the desired product (2a-q).
References:
Ferreira, Irlon M.;Casagrande, Gleison A.;Pizzuti, Lucas;Raminelli, Cristiano [Synthetic Communications,2014,vol. 44,# 14,p. 2094 - 2102] Location in patent:supporting information
121-33-5
1219 suppliers
$9.00/1g
5438-36-8
154 suppliers
$29.00/5g
![6,6'-DIHYDROXY-5,5'-DIMETHOXY-[1,1'-BIPHENYL]-3,3'-DICARBOXALDEHYDE](/CAS/GIF/2092-49-1.gif)
2092-49-1
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37987-21-6
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5438-36-8
154 suppliers
$29.00/5g
121-33-5
1219 suppliers
$9.00/1g
19463-48-0
115 suppliers
$24.00/1g
5438-36-8
154 suppliers
$29.00/5g