5-METHOXY-2-METHYLINDOLE synthesis
- Product Name:5-METHOXY-2-METHYLINDOLE
- CAS Number:1076-74-0
- Molecular formula:C10H11NO
- Molecular Weight:161.2
Yield:1076-74-0 94%
Reaction Conditions:
with acetic acid for 8 h;Reflux;Large scale;Reagent/catalyst;
Steps:
1; 2; 3 Example 2
Under stirring at room temperature, 4.2Kg of p-methoxyaniline, 2.9Kg of hydroxyacetone and 25Kg of acetic acid were added to the 50L glass reactor in turn, and the mixture was mixed well.The reaction solution was heated to reflux reaction, and the reaction was kept at reflux for 8 hours, and the reaction was completed.The reaction solution was distilled under reduced pressure to recover acetic acid. The residue was recrystallized with acetonitrile, and then vacuum oven dried to obtain 5.2Kg of off-white solid powder product with a yield of 94%.
References:
CN111253297,2020,A Location in patent:Paragraph 0035-0041; 0049-0054; 0062-0067
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