5-METHYLGRAMINE synthesis
- Product Name:5-METHYLGRAMINE
- CAS Number:30218-58-7
- Molecular formula:C12H16N2
- Molecular Weight:188.27
50-00-0
910 suppliers
$10.00/25g
614-96-0
319 suppliers
$19.00/1g
124-40-3
544 suppliers
$18.00/100ml
30218-58-7
66 suppliers
$45.00/50mg
Yield:30218-58-7 65%
Reaction Conditions:
Stage #1: formalin;5-methyl-1H-indole;dimethyl aminewith glacial acetic acid in tetrahydrofuran;1,4-dioxane;lithium hydroxide monohydrate at 0 - 20;Inert atmosphere;
Stage #2: with sodium hydroxide in tetrahydrofuran;1,4-dioxane;lithium hydroxide monohydrate;
References:
Bandini, Marco;Eichholzer, Astrid [Angewandte Chemie - International Edition,2009,vol. 48,# 50,p. 9533 - 9537] Location in patent:supporting information; experimental part