5-Nitroindole synthesis
- Product Name:5-Nitroindole
- CAS Number:6146-52-7
- Molecular formula:C8H6N2O2
- Molecular Weight:162.15
In 500ml round bottom flask add 27.2g2-sodium-1-acetylindole (0.1mo1), add 100ml acetic acid, cool down to 12°C, in 1h dropwise finish 19ml fuming nitric acid, the reaction is complete, carefully poured into 250ml crushed water, add 160gNaOH, slowly ra
6625-96-3
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6146-52-7
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Yield:6146-52-7 90%
Reaction Conditions:
with perchloric acid adsorbed on silica gel;anthranilic acid amide in acetonitrile at 80; for 6 h;
Steps:
Typical procedure for the deformylation of indole and azaindole-3-carboxaldehydes
General procedure: Solid acid catalyst (50% w/w) was added to the solution of indole-3-carboxaldehydes 1a-1h or azaindole-3-carboxaldehyde 6 (1 mmol) and anthranilamide 2a (1 mmol) in acetonitrile (6 mL). The reaction mixture was allowed to stir for 6-24 h at room temperature or at reflux temperature. The progress of the reaction was monitored by TLC. After completion of the reaction, it was allowed to cool and catalyst was recovered by filtration. The filtrate was concentrated to get crude products which after silica gel (No.100-200) column chromatography gave deformylated products 4a-4h or 5 in 25-90% yield.
References:
Yadav, Rammohan R.;Battini, Narsaiah;Mudududdla, Ramesh;Bharate, Jaideep B.;Muparappu, Nagaraju;Bharate, Sandip B.;Vishwakarma, Ram A. [Tetrahedron Letters,2012,vol. 53,# 17,p. 2222 - 2225] Location in patent:experimental part
32692-19-6
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6146-52-7
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17422-32-1
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6146-52-7
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125600-42-2
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6146-52-7
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166104-19-4
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6146-52-7
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