6-Amino-1,3-dimethyl-5-(methylamino)-2,4(1H,3H)-pyrimidinedione synthesis
- Product Name:6-Amino-1,3-dimethyl-5-(methylamino)-2,4(1H,3H)-pyrimidinedione
- CAS Number:54729-62-3
- Molecular formula:C7H12N4O2
- Molecular Weight:184.2
Yield:54729-62-3 90%
Reaction Conditions:
in ethanol at 20 - 30; for 12 h;
Steps:
12; 16
6-Amino-5-chloro-1,3-dimethylpyrimidinyl-2,4-dione (10.4 g, 54.8 mmol) was suspended in ethanol, and a solution of 30% methylamine in ethanol (28.3 g, 274 mmol) was added. ), reacting at 20-30 ° C for 12 hours, the reaction is almost complete. Concentrated, add dichloromethane, water, the organic phase is concentrated, recrystallized with water, dried to give a white solid6-amino-1,3-dimethyl-5-(methylamino)pyrimidinyl-2,4-dione8.4 g, yield 90%.
References:
CN108912121,2018,A Location in patent:Paragraph 0157; 0158; 0160; 0181; 0182; 0184
6642-31-5
396 suppliers
$5.00/10g
54729-62-3
14 suppliers
inquiry