2H-Pyran-4-carboxylicacid,tetrahydro-,hydrazide(9CI) synthesis
- Product Name:2H-Pyran-4-carboxylicacid,tetrahydro-,hydrazide(9CI)
- CAS Number:59293-18-4
- Molecular formula:C6H12N2O2
- Molecular Weight:144.17
110238-91-0
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59293-18-4
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Yield:59293-18-4 98%
Reaction Conditions:
with hydrazine monohydrate in methanol at 20;Reflux;Inert atmosphere;
Steps:
241 oxane-4-carbohydrazide
To a stirred solution of methyl tetrahydro-2H-pyran-4-carboxylate (4 g, 27.75 mmol) in MeOH (50 mL) at RT, hydrazine monohydrate (10.8 mL, 222 mmol) was added portion-wise and the resulting reaction mixture was stirred at reflux O/N. The mixture was allowed to reach RT and concentrated under vacuum affording the title compound oxane-4-carbohydrazide (p241 , 3.9 g, y= 98%) as white solid. MS (/T7/z): 145.1 [MH]+.
References:
WO2016/67043,2016,A1 Location in patent:Page/Page column 154
5337-03-1
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59293-18-4
44 suppliers
$63.00/200μmol