6-(4-CHLOROPHENOXY)NICOTINONITRILE synthesis
1synthesis methods
- Product Name:6-(4-CHLOROPHENOXY)NICOTINONITRILE
- CAS Number:99902-70-2
- Molecular formula:C12H7ClN2O
- Molecular Weight:230.65
Yield:99902-70-2 93%
Reaction Conditions:
Stage #1: 4-chloro-phenolwith sodium hydride in N,N-dimethyl-formamide at 20; for 4 h;
Stage #2: 6-chloronicotinonitrile in N,N-dimethyl-formamide at 100; for 10 h;
References:
Guan, Aiying;Liu, Changling;Chen, Wei;Yang, Fan;Xie, Yong;Zhang, Jinbo;Li, Zhinian;Wang, Mingan [Journal of Agricultural and Food Chemistry,2017,vol. 65,# 6,p. 1272 - 1280]