6-Butylnicotinaldehyde synthesis
2synthesis methods
- Product Name:6-Butylnicotinaldehyde
- CAS Number:181937-07-5
- Molecular formula:C10H13NO
- Molecular Weight:163.22
Yield:181937-07-5 55%
Steps:
8
Reagents: i) 1-Butaneboronic acid, 55%; ii) Ethyl acrylate ; iii) NaOH, total yield of the two steps was ~60%.LC/MS data of 2805D - Calculated MW is 219; observed (the peak of 20.9 min): 220[M+H].Gradient: 0-5 min: 2% ACN; 5-20 min: 2-30% ACN; 20-35 min: 30-98% ACN.
References:
WO2008/16968,2008,A2 Location in patent:Page/Page column 71
