6-Chlorohexanoic acid synthesis
- Product Name:6-Chlorohexanoic acid
- CAS Number:4224-62-8
- Molecular formula:C6H11ClO2
- Molecular Weight:150.6
52387-36-7
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4224-62-8
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Yield:4224-62-8 81%
Reaction Conditions:
with N-hydroxyphthalimide;oxygen in acetonitrile at 30; for 3 h;Schlenk technique;
Steps:
13 Synthesis of 6-chlorohexanoic acid
15 mol% NHPI was added to a 25 mL Schlenk reaction tube, dried under vacuum for 15 minutes, oxygen was bubbled in, and 2 mL of acetonitrile and 1.0 equivalent of 6-chlorohexanal were added in an oxygen atmosphere, and an oxygen balloon was attached thereto, and a glass stopper was added to the reaction tube. After that, it was placed in an oil bath and reacted at 30 ° C for 3 h. After the completion of the reaction, the mixture was concentrated under reduced pressure and purified by column chromatography, eluting with petroleum ether / ethyl acetate / methylene chloride (v: v: v = 5:1:1) to give 6-chlorohexanoic acid. Yield 81%,Colorless liquid
References:
University of Science and Technology of China;Kang Yanbiao;Dai Pengfei CN108314599, 2018, A Location in patent:Paragraph 0041-0043
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