6-IODO-2,3-DIMETHOXYPYRIDINE synthesis
- Product Name:6-IODO-2,3-DIMETHOXYPYRIDINE
- CAS Number:321535-23-3
- Molecular formula:C7H8INO2
- Molecular Weight:265.05
124-41-4
724 suppliers
$12.00/25g
321535-37-9
117 suppliers
$55.00/250mg
321535-23-3
85 suppliers
$113.00/250mg
Yield:321535-23-3 85%
Reaction Conditions:
in N,N-dimethyl-formamide at 100; for 2 h;
Steps:
1 Step 1: 6-iodo-2, 3-dimethoxypyridine
To a solution of 2-bromo-6-iodo-3-methoxypyridine (2.5 g, 7.96 mmol) in DMF (20 mL) was added MeONa (602.33 mg, 11.15 mmol, 5.4 M) at 20 . The solution was stirred at 100 for 2 hrs. The reaction was added H2O (50 mL) , extracted with MTBE (50 mL ×3) . The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, eluent: PE/EA (v/v) = 50/1 to 10/1) to give 6-iodo-2, 3-dimethoxypyridine (2.5 g, yield: 85%) as a white oil.
References:
WO2021/208963,2021,A1 Location in patent:Paragraph 0847-0849
67-56-1
793 suppliers
$9.00/25ml
124-41-4
724 suppliers
$12.00/25g
321535-37-9
117 suppliers
$55.00/250mg
321535-23-3
85 suppliers
$113.00/250mg