6-ISOBUTYLQUINOLINE synthesis
- Product Name:6-ISOBUTYLQUINOLINE
- CAS Number:68141-26-4
- Molecular formula:C13H15N
- Molecular Weight:185.26
Yield: 80%
Reaction Conditions:
with dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane;tris-(dibenzylideneacetone)dipalladium(0) in toluene for 18 h;Inert atmosphere;Reflux;
Steps:
1 Synthesis of 1.6-(2-methylpropyl)quinoline
80 g (0.38 mmol) of 6-bromoquinoline, 78.4 g (0.77 mol) of isobutylboronic acid,Tris(dibenzylideneacetone)dipalladium (2 mol%), 2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl(4 mol%),Potassium phosphate monohydrate 354 g (1.54 mol), 800 mL of toluene, nitrogen replacement,The reaction was left to reflux under a nitrogen atmosphere for 18 hours.The reaction system was cooled to room temperature, and the eluent was purified by n-hexane/ethyl acetate = 100/2.57 g (yield: 80%) of 6-(2-methylpropyl)quinoline were obtained.
References:
Yurui (Shanghai) Chemical Co., Ltd.;Zheng Xianzhe CN109232656, 2019, A Location in patent:Paragraph 0052-0054
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