6-(PERFLUOROHEXYL)HEXANOL synthesis
- Product Name:6-(PERFLUOROHEXYL)HEXANOL
- CAS Number:161981-35-7
- Molecular formula:C12H13F13O
- Molecular Weight:420.21
177722-97-3
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161981-35-7
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Yield:161981-35-7 97%
Reaction Conditions:
with zinc in ethanol at 50; for 4 h;
Steps:
45.2 Steo-2: 7,7, 8, 8,9,9, 10, 10,11,11, 12, 12, 12-Tridecafluorododecan-1-ol
To a slurry of zinc (23.94 g, 386 mmol) in ethanol (50 mL) was added 7,7,8,8,9,9,10,10,11,11,12,12,12-tridecafluoro-5-iodododecan-1-ol (40g, 73.2 mmol). The reaction mixture was heated at 50 °C for 4 h. TLC showed presence of new compound. The reaction was concentrated to dryness. The crude product was purified by silica gel chromatography to afford 7,7,8,8,9,9,10,10,11,11,12,12,12-tridecafluorododecan-l-ol (30 g, 71.4 mmol* 97 % yleld). 1H NMR (400 MHz, CDCb): d 3.64 (t, J = 16.0, 6.4 Hz, 2H), 2.08-2.03 (m, 2H), 1.64-1.59 (m, 4H), 1.43-1.40 (m, 4H).
References:
WO2021/194828,2021,A1 Location in patent:Page/Page column 159-160
821-41-0
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130233-16-8
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161981-35-7
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355-43-1
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