6-Quinazolinecarboxaldehyde (9CI) synthesis
- Product Name:6-Quinazolinecarboxaldehyde (9CI)
- CAS Number:439811-22-0
- Molecular formula:C9H6N2O
- Molecular Weight:158.16
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Yield:439811-22-0 68%
Reaction Conditions:
with 2,6-dimethylpyridine;sodium periodate;osmium(VIII) oxide in 1,4-dioxane;water;tert-butyl alcohol at 20; for 0.5 h;
Steps:
1.d
A mixture of the vinyl compound from example 1c (65 mg, 0.416 mmol), 2.5% osmium tetraoxide in f-butanol (85 mg, 0.008 mmol), sodium periodate (356 mg, 1.66 mmol) and 2,6-lutidene (97 μl_, 0.833 mmol) in dioxane (3mL) and water (1 ml_) was stirred at RT for 30 min. The reaction mixture was diluted with water (10 ml_) and extracted with DCM (2 x 30 ml_).The organic layer was dried over MgSO4, filtered and solvents removed under reduced pressure to yield the title compound (45 mg, 68%) which was used in the next step without further purification. C9H6N2O MS(ES+) m/e 159 [M+H]+
References:
WO2007/38331,2007,A2 Location in patent:Page/Page column 28
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