6-UNDECANOL synthesis
- Product Name:6-UNDECANOL
- CAS Number:23708-56-7
- Molecular formula:C11H24O
- Molecular Weight:172.31
927-49-1
168 suppliers
$13.43/1gm:
23708-56-7
93 suppliers
$9.00/1g
Yield:23708-56-7 93%
Reaction Conditions:
with sodium tetrahydroborate in tetrahydrofuran;methanol at 0 - 20; for 2 h;
Steps:
2.3 ATX-43: Step 3
To a solution of 15 g undecan-6-one (1 eq.) dissolved in 25 ml methanol (MeOH) in 150 ml THF, 4.9 g sodium borohydride (1.5 eq.) was added at 0° C. and the resulting solution was stirred at room temperature for 2 hour. Progress of the reaction was monitored by TLC (10% EtOAc in hexane; Rf: 0.5). Reaction mass was quenched with saturated NH4Cl solution (100 ml). Solvent was removed under reduced pressure and the resulting crude was portioned between EtOAc (150 ml) and water (150 ml). Organic layer was separated and the aqueous layer was washed with EtOAc (3×100 ml). Combined organic layers were concentrated under reduced pressure to get white solid. Quantity produced, 14.0 g; yield, 93%.
References:
Arcturus Therapeutics, Inc.;Payne, Joseph E.;Chivukula, Padmanabh;Karmali, Priya;Tanis, Steven P. US2018/169268, 2018, A1 Location in patent:Paragraph 0019; 0157-0159
142-62-1
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$13.80/2.5g
23708-56-7
93 suppliers
$9.00/1g
64214-56-8
26 suppliers
$45.00/100mg
23708-56-7
93 suppliers
$9.00/1g
142-61-0
250 suppliers
$9.00/1g
23708-56-7
93 suppliers
$9.00/1g