(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZIN-2-YL)ACETIC ACID synthesis
- Product Name:(3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZIN-2-YL)ACETIC ACID
- CAS Number:6270-74-2
- Molecular formula:C10H9NO3S
- Molecular Weight:223.25
Yield:6270-74-2 98%
Reaction Conditions:
in diethyl ether at 25;Inert atmosphere;regioselective reaction;
Steps:
2-(3-Oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetic Acid (5)
To a stirred solution of maleic anhydride (4, 2.45 g, 25 mmol) in Et2O (40 mL) was added o-aminothiophenol (2, 3.13 g, 25 mmol) in a dropwise fashion at 25 °C under argon; the mixture was stirred for 1 h. The separated precipitate was filtered on a Buchner funnel and washed with Et2O (25 mL). The obtained product was dried under vacuum to give pure acid 5; yield: 5.50 g (98%); mp 181-182 °C (MeOH).
References:
Jangir, Ravi;Gadre, Smita R.;Argade, Narshinha P. [Synthesis,2015,vol. 47,# 17,art. no. SS-2015-Z0050-OP,p. 2631 - 2634]
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7291-93-2
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6270-74-2
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137-07-5
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6270-74-2
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$24.10/1G